Repurposing as a Future Strategy for Pharmaceutical Research

Repurposing as a Future Strategy for Pharmaceutical Research With the urgent need for new treatments for serious diseases and concerns about other existing unmet patient needs as well as the cost of traditional drug discovery and other productivity issues on the constant increase, drug repurposing has become an attractive alternative. Drug repurposing is defined as the process of discovering new indications for existing drug compounds (Tari and Patel, 2014). Tari Patel (2014) further explain that the concept behind drug repurposing is â€Å"that novel drug indications can be identified based on the principle that a primary drug target can be associated with diseases other than its original drug indication.† Various systematic approaches have been proposed for finding new indications for drugs; some of this include discovering drugs hat share a significant number of side effects as they may have similar actions and those with similar chemical compounds. The most cited success for drug repositioning is sildenafil, a drug developed by Pfi zer and originally indicated for the treatment of angina but was discovered to show an improvement in patients suffering from erectile dysfunction as well (Pantziarka et al, 2014) [online] Drug repurposing is becoming the surest way to both provide treatment for both new and old diseases, as well as reducing greatly the cost of production of these treatments. Persidis (2011) [online] lists a couple of advantages crediting this, some of which include that pre-existing drugs or those which have been proven to be safe at late-stage trials greatly reduce development risk even when repurposed for potentially new indications. The article continues to add that there is a massive money saving advantage when comparing launching a repurposed drug into the market with launching a completely new formulation to pharmaceutical companies owning original use rights to the drug. On the other hand, NCBI suggests that as drugs are only approved for specific therapeutic indications within clear safety boundaries and after intense investigation, finding new drug-target interactions is most often hampered by safety issues regarding dosage and delivery capability as discovery of a repurposed drug working within the approved therapeutic window is a rare occurrence; suggesting also that even in a case where appropriate formulations and delivery devices were available to eliminate the problems associated with dosage and delivery within the narrow therapeutic window, the issue of lack of integration with pharmaceutical and toxicological sciences still persists. These go without including the problems associated with protection of intellectual property as various new drug-target-disease triplets are often disclosed by various online databases. Repositioned drugs have been a huge success in providing effective remedies for a large number of patients suffering from a wide range of diseases, have promised to deliver new treatments for even more diseases including some of the most perverse diseases the plague the central nervous system, cardio-vascular system, many metabolic disorders and cancer. Precisely, the scope of drug repurposing can be widened in future to cater for the development of drugs with multiple targets as in the area of oncology and those which target disease in various ways as in obesity. It can even more importantly create opportunities for the development of second-generation drugs (Sehkon, 2013) Therefore, despite any disadvantages that may arise in the process of repositioning drugs, the process remains the most effective of its kind in recent times and hence plays a very important role in pharmaceutical research concerning future drug discovery. It is important to note that though most repurposed drugs have desirable pharmacokinetic and pharmacodynamics properties especially those that have passed various clinical trial stages about 2000 of these drugs lie dormant of various companies’ shelves and Barratt and Frail (2012) suggest that this number grows at the rate of 150-200 drugs every year. Sequentially, this number creates more than adequate substrate on which a repurposing strategy can be developed and as discontinued compounds are a by-product of carrying out business in the pharmaceutical environment, there will never be a shortage of them. Hence, learning from these failures and applying the ever evolving science behind human biology and diseases will not only salvage efforts made in the research and development environment but also lead to the development of a very viable business model while significantly decreasing the risk of failure, cost of production and cycle time. Bibliography Sehkon, BS 2013, ‘Repositioning drugs and biologics: Retargeting old/existing drugs for potential new therapeutic applications’, Journal Of Pharmaceutical Education Research, 4, 1, pp. 1-15, Academic Search Index, EBSCOhost, viewed 18 November 2014. Tari, L. B. and Patel J. H. (2014) [online] ‘Systematic Drug Repurposing Through Text Mining’ Biomedical Literature Mining vol. 1159, pp. 253-267 Available at: http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-4939-0709-0_14 [Accessed: 18th November, 2014] Barratt, M. J. and Frail, D. E. (2012) Drug repositioning: Bringing New Life to Shelved Assets and Existing Drugs John Wiley Sons, Inc. Pantziarka, P., Bouche, G., Meheus, L.., Sukhatme, V., Sukhatme, V. P. (2014) [online] ‘The Repurposing Drugs in Oncology (ReDO) Project’ ecancermedicalscience pp. 3 Available at: http://ecancer.org/journal/8/full/442-the-repurposing-drugs-in-oncology-redo-project.php [Accessed: 17th November, 2014] Persidis, A. (2011) [online] ‘The benefits of drug repositioning’ Drug Discovery World Available at: http://www.ddw-online.com/business/p142737-the-benefits-of-drug-repositioning-spring-11.html [Accessed: 17th November, 2014] Tudor I. Oprea, Julie E. Bauman,Cristian G. Bologa, Tione Buranda, Alexandre Chigaev, Bruce S. Edwards, Jonathan W. Jarvik, Hattie D. Gresham,Mark K. Haynes,Brian Hjelle,Robert Hromas,Laurie Hudson,Debra A. Mackenzie,Carolyn Y. Muller,John C. Reed,Peter C. Simons,Yelena Smagley,Juan Strouse, Zurab Surviladze,Todd Thompson,Oleg Ursu,Anna Waller,Angela Wandinger-Ness,Stuart S. Winter,Yang Wu,Susan M. Young,Richard S. Larson,Cheryl Willman,andLarry A. Sklar (2012) [online] ‘Drug repurposing from an academic perspective’

Marketing Skoda

I have chosen Soda because I believe they are a very creative and innovative car company, from heir recent adverts of building their cars with cakes and other foods, this shows Soda are very creative, and this made me choose Soda. Before the adverts Soda were relatively unknown to me personally, however after seeing their creative adverts they stand out more as an organization. Explaining Soda Soda started of making bicycles; this is quite strange because it shows the creativity within the organization.They started of making bicycles and now they are making cars. Soda is a Czech company; however they have merged with the German car company Volkswagen. The history of Soda's rise from being a running Joke to becoming the most deservedly respected name In the car world is one of the triumphs of the modern era. Marketing communications At Its best creative marketing can have a huge effect on sales. This Is also backed up by the greatest thinker in the world Albert Einstein. Imagination i s more important than Knowledge' Marketing communications attempts to affect an audience response either rationally or emotionally. Objectives are written as hard or soft, goals such as attitudinal and behavioral, which then translate into awareness, column inches, evoked and inconsideration sets, leads conversations and coupon responses. Jenkins (2006) ‘Advertising relies on visual imagery to connect the perceptual with the conceptual, the signifier and the signified, the product and the product benefits. Schroeder and Borrowers (2005) Talking about sensory The reaction of the viewers Is Important for Soda, The vowels reaction to marketing communications that Is meaningful and allows people to make sense of the presented message, to interpret the creative images. Movement and direction Our primitive instincts make us react very quickly to movement. Advertisements with motion get increased attention and movement may make the advertisement much more dynamic and creates better i mpact. This is important because it helps the target audience to stay focused and pay attention.I believe Soda have done this very creatively. In their advert there is a lot of movement and the advert is like an adventure, it makes the target audience watch in anticipation because they want to know what happens next. As we know people have short attention spans and movement Is an effective tool to help the audience focus. The powerful effect of action Intensive advertising explains why TV and cinema advertising Is so effective. Color and Intensity Advertising with a lot of color draws attention to It.Color makes advertising more intense and can also make people pay attention for a longer time as we enjoy being sauce Dye Intense stimuli. color Is not only a tool to get people's attention; It also sets the mood in advertising. Soda has done this very well as they have a different number of colors in their advertisement. This sets the mood and also grips the audience. The color Soda us e throughout their advertisement is green, green is now as a peaceful and calm color this is very creative because the audience will feel relaxed while watching the advertisement.Size and contrast Size is a good creative tool to use. It can be used with large letters, images and illustrations. If the advertisement is large the empty advertisement will generate curiosity. This is what is regularly called negative space in advertising. Contrast is an effective tactic in advertising. Soda use this very well on billboards, as they have a large car and have their workers around the car, and there is a green background, it s simple yet odd, this is what will get the audience attention.Sound The advertising Soda use is creative advertising on a big scale. It's imaginative, ambitious, painstakingly crafted and thanks in no small part to the soundtrack of Julie Andrews singing my favorite things. The sound that Soda us in their advert is enticing and draws the attention of the audience. It m akes the audience want to know what happens next? It is exciting for the viewers. The beginning of the advert sets the tone for the advert, the start of the advert is important because if it is not the attention of the viewers will be gone.Sound is an integral ingredient in any advert, the reason being is that sound attempts to draw the viewers into the advert to improve their viewing experience. Soda knows advertising plays a huge part in customer's decision making process of which products and services to use, often without them even realizing, in particular television adverts, because of the vast expanse of potential customers they reach. They are a powerful tool in the marketing scheme of companies which can be used to access millions of homes and influencing people.The song Soda use for their advert is catchy and grips the audience, in the background a car is being made with cakes and the song is mellow so they fit in well together. Sound is a very powerful marketing tool. I be lieve the sound in the Soda advert arouses peoples attention, simply because when adverts come on consumers attention is not 100% compared to the consumer watching their program, therefore the sound needs to be used appropriately, I believe Soda use this very well because it is a catchy song and also a song that is not too loud and also the song is very rhythmic.Verbal taste We eat with our eyes before we smell or taste. This is the taste sense. The cake advert Soda has does exactly this, We know people eat with their eyes before they smell or taste, therefore The advert shows employees of Soda making a car out of Cakes, people love to eat cakes, therefore as soon as the viewers see the cakes there senses are triggered and the viewers like cake therefore they will like the car.This is very creative from Soda as viewers will be looking at the advert and thinking what is this? I want this? It will Stick in peoples head, resulting in a better brand awareness or Soda. Humans have 10,000 taste buds therefore the advert is going to appeal to them, as soon as we see cake it triggers our taste buds and we want it. Next time a viewer is looking to buy a car they may think in their heads I want that cake car, and cakes are tasty odometer ten cake car wall De stagnantly Ana enjoys el D .Osaka use ten taste sense very well because as consumers are watching the adverts of the Soda cars it makes them want to actually taste the car as different ingredients are used to create the car creating a sense of hunger within the consumer, and Soda cars could et consumers bipartite, as the eyes are more hungrier than the mouths. Visual is images Human sight has limited range 2/3rd of the sense cells in the body are located in the eye.This shows the importance of sight, the advertisement needs to be enjoyable and eye catching, if the viewers see images they don't like then this could be very harmful for Soda because it will create a negative image for the company. Throughout the advert soda has used a different approach to conventional marketing as it has betrayed the car as a cake . This marketing campaign will show the viewers hat soda has put in a lot of time and effort so everything is made effectively and effectively.Soda has clearly illustrated that every part every nut and bolt is hand crafted so this will appeal to customers as they have seen the car being made with their eyesight. Through the advert and also on the Soda website color has been used effectively as it has bright colors creating a relaxed mood, the color red is not used because this will automatically trigger danger signs into viewers minds. The visual images Soda use are very good on both the television and internet adverts. The website is very colorful and has great visual aids like videos and color.The television advertisement has a number of different colors, this sets the mood of the advert and gets the consumers attention, the consumers will be thinking wait a minute what have we got h ere? I want to watch this and it is also a catchy advert therefore consumers will remember this and it will enable consumers to think about Soda cars next time they are looking to purchase a new car. Tactile touch Soda has made a very effective marketing campaign illustrating the fun factor in soda vehicles.The fun factor is clearly visible which the customer can connect with resulting in customers wanting to have fun which is connected to soda vehicles. Advert makes the viewers want to help touch the car, by helping to build the car because the employs are having so much fun building the car, also when the car is finished the viewers may want to drive a Soda as they know how much fun has gone into creating the car. I believe the Soda advert ticks all the boxes of 7 dimensions used to measure likeability. I believe the advert makes the viewer want to touch the car o see how it feels and to also be apart in creating the car.The advert makes the viewer want to move closer to the adver t rather than move away from it because the adverts creates a sense of happiness. Genetics on Soda Genetics is all about how we communicate feelings, how we shape sounds and products. From the Soda adverts, billboards and website it makes us want to move closer to the company rather than move away, as they are all very appealing and are colorful. The advertisements for Soda are slender than many other car companies because the adverts show innovativeness and creativity.The Marketing for Soda also makes the customers happy, because the adverts and website are very colorful and there is a lot going on like moving objects. The marketing aspect of Soda has a tranquility about it because there advertisements inspire people who have seen them. How It can De enhance The most fundamental tool that facilitates learning is arousal. When people in the target market get aroused they raise their awareness and their ability to react to new stimuli. The brain automatically interprets the arousal a s being something important and important things must be memorized.By using powerful elements in advertising that creates arousal in the target audience the marketer can increase receptivity to the message. I believe Soda have a creative marketing campaign however to hammer their advertising on people they need to keep creating adverts like they have been doing but using them at the right time. By this I mean arousing customers is good however by placing the advertisement in an arousing context, this will help Soda more because by having their adverts on billboards in major football matches will arouse customers more as they are already aroused by the football match. I feelSoda have a great marketing campaign in place however I feel if Soda promised their customers a free cake with every purchase this could be a good marketing strategy because it carry on the add and for most people their senses will show when they see a cake in the bakery or supermarket they associate the cake with Soda. How Soda grab customers attention The most fundamental tools to gain peoples attention and to sustain their interest originate in perceptual psychology. Atkinson and Hillary (1996) Perception ability is a basic human trait that helps us react intuitively to outside stimuli that may be important.The advertising tool Soda use in advertising is appealing to peoples natural instincts and they also try to make their advertisements stand out to get the target audience to pay attention and process the brand image. Creativity compared to rivals If a customers goes on the Soda website they will feel exited and want to explore the website as color is used very efficiently, however if a consumer was to go on the BMW website is is boring and the customer will want to navigate away from the site as it has a lot of information on it and is very dull. The senses will react more on the Soda Bessie than the other car websites.The adverts are far more creative than their rivals also as Mercede s and BMW feel their brand name will sell, Soda has won a number of awards for their cars and this is displayed on their website, this shows Soda is a progressing organization. Reflective account I feel this course has changed my perceptions on marketing. Simply because before this module I would look at marketing of companies and not pay attention, however now I look at them differently. I analyses the marketing strategies in my head and think to myself why have they done this? Why didn't they do this?I was looking at the new polo car advert in the advert their is a man and a women dancing all they do in the advert is dance then a Polo car badge appears, this is very boring and dull, I thought to myself why didn't they use the advert better by having something to do with the car itself as it is a new model car and include different colors in the advert, the actual advert loses my interest within the first three seconds. I now look at creative marketing in a different way, in a funn y kind of way my eyes have opened up now and I am 22 years old. I wish I did this module earlier as I could of used my knowledge I have gained.I believe creativity is very important for marketing, it can be uses In a Deterrent under AT ways, never I nave also learned Tanat It NAS to one used effectively in order to get the best results. I have learnt how we think as individuals, through our sensory triggers, I have also learnt how to put a creative thought into execution through the tutorials. I have learnt how creativity can influence consumer behavior and how creativity can influence our thinking about consumer wants and desires. Creativity is also a key determinant in the development of innovation, in both business and management.

Standard Deviation and Cumulative Frequency

Statistics-1 1. One thousand candidates sit an examination. The distribution of marks is shown in the following grouped frequency table. Marks|1–10|11–20|21–30|31–40|41–50|51–60|61–70|71–80|81–90|91–100| Number of candidates|15|50|100|170|260|220|90|45|30|20| (a)Copy and complete the following table, which presents the above data as a cumulative frequency distribution. (3) Mark|? 10|? 20|? 30|? 40|? 50|? 60|? 70|? 80|? 90|? 100| Number of candidates|15|65|||||905|||| b)Draw a cumulative frequency graph of the distribution, using a scale of 1 cm for 100 candidates on the vertical axis and 1 cm for 10 marks on the horizontal axis. (5) (c)Use your graph to answer parts (i)–(iii) below, (i)Find an estimate for the median score. (2) (ii)Candidates who scored less than 35 were required to retake the examination. How many candidates had to retake? (3) (iii)The highest-scoring 15% of candidates were awarded a distin ction. Find the mark above which a distinction was awarded. (3) Total 16 marks) 2. At a conference of 100 mathematicians there are 72 men and 28 women. The men have a mean height of 1. 79 m and the women have a mean height of 1. 62 m. Find the mean height of the 100 mathematicians. (Total 4 marks) 3. The mean of the population x1, x2, †¦Ã¢â‚¬ ¦.. , x25 is m. Given that = 300 and = 625, find (a)the value of m; (b)the standard deviation of the population. (Total 4 marks) 4. A supermarket records the amount of money d spent by customers in their store during a busy period.The results are as follows: Money in $ (d)|0–20|20–40|40–60|60–80|80–100|100–120|120–140| Number of customers (n)|24|16|22|40|18|10|4| (a)Find an estimate for the mean amount of money spent by the customers, giving your answer to the nearest dollar ($). (2) (b)Copy and complete the following cumulative frequency table and use it to draw a cumulative frequency graph . Use a scale of 2 cm to represent $20 on the horizontal axis, and 2 cm to represent 20 customers on the vertical axis. (5) Money in $ (d)|

Magnificent Catastrophe Essay - 1061 Words

Critical Book Review #1 In the book â€Å"A Magnificent Catastrophe† the author, Edward J. Larson, writes about all of the little details that has occurred in the First Presidential Campaign in the 1800s. He begins his book with how the two parties, the Republicans (Jefferson) and Federalists (Adams), were going to compete in who will govern the United States now that it is a free country and no longer under Britain’s rule. Although they had at first been friends they soon became enemies because of how they believed the government should be. Jefferson believed that the government should be a populist government that trusted popular rule. While Adams believed that America should have a strong government and that al†¦show more content†¦Inputting the photographs of the men of that time put a face to who was talking and what their thoughts were about at the time. Having the photographs of the electoral votes taught me how they were shown to people in the newspapers and what each state vo ted for. The 1793 cartoon that showed Thomas Jefferson leading the Federalists in a meeting taught me that people really thought they were evil and horrible people as there is a devil in the corner watching the men talk. Also, Larson has inserted at the end of his book pages titled Notes which helps the readers see exactly where he got his information from and the years and by who in which had originally wrote the information. The pages titled Notes is a positive because it shows that his evidence that he found about the election is credible. The photographs, the small background details, and the pages titled Notes are the positives that Larson has contributed in his book. The negative aspects of this book was that it was boring to me. Although I did learn a lot from it it did not catch my interest of wanting to read other books that cover this topic of the election. Another negative aspect is that the diction that were used in the book were most of the time confusing and I did not understand it. Larson could have inserted some more interesting events that occurred during the election. Although this book taught me more about the election I did not find it interesting and the diction thatShow MoreRelatedA Magnificent Catastrophe By Edward J. Larson1780 Words   |  8 PagesThe book A Magnificent Catastrophe, by Edward J. Larson, narrates a story about how dirty and devious America’s first presidential campaign of 1800, how it became the most powerful election and how it molded America’s future in today’s society. Adams and Jefferson two great friends that shared one common goal. It is to obtain America’s freedom against the motherland Great Britain. 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As she wrote Frankenstein, Mary Shelley also experienced a magnificent and grand environment. Mary Shelley’s love of nature, and an 1816 summer storm that she witnessed while writing Frankenstein influenced nature’s role as a pillar of comfort, inspiration, and hope amidst tragedy, struggle, and ruin in her novel.Read MoreThe Great Fire Of London1142 Words   |  5 PagesFire of London portrays the harsh reality of a devastating catastrophe: the burning of an entire city and the steps taken towards the recreation of a thriving empire. The Great Fire of London began in the primordial hours of the morning in the house of King Charles II’s baker on Pudding Lane adjacent to the London Bridge (â€Å"Great Fire of†¦Ã¢â‚¬  1). Tomas Farynor, the King’s baker, was the man believed to have been the fuel source of the catastrophe. 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